Parathyroid Q&A is a community of experts and patients dedicated to understanding and treating Parathyroid Disease.


Hi Dr Boone. I have high calcium. Does it mean I have parathyroid disease? Also your website doesn’t mention primary parathyroid disease. Is it by design? Thanks.

Deva Boone
Answer authored by Deva Boone
Deva Boone, MD is the founder of the Southwest Parathyroid Center. As one of the most experienced parathyroid surgeons in the U.S., she has treated thousands of patients with parathyroid conditions.

High calcium is almost always caused by parathyroid disease (specifically, primary hyperparathyroidism), but just knowing a calcium level is not enough for a definitive diagnosis. We also need to see a PTH level. Once you have a calcium and PTH level together (ideally taken from the same day), you can usually make the diagnosis. A high calcium combined with a high or normal PTH is diagnostic of primary hyperparathyroidism in most cases. For help with this, check out the Parathyroid Disease Analysis App.

Regarding primary parathyroid disease: Primary hyperparathyroidism is the most common form of parathyroid disease, and when people talk of “parathyroid disease” we are usually referring to primary hyperparathyrodism. But secondary hyperparathyroidism should be recognized also. Some web sites on parathyroid disease are focused heavily on primary hyperparathyroidism, to the point where “parathyroid disease” becomes synonymous with “primary hyperparathyroidism.” On this site, I want to distinguish and explain the different forms, since secondary and primary hyperparathyroidism are often confused.

Diagnosis Primary HPT